In response to high circulating IGF-1,
active AKT regulates multiple downstream transcription factors and regulatory
proteins. Beyond inhibiting BAD, how does AKT concurrently prevent apoptosis
and drive cell division?

Question

Accepted Answer

AKT phosphorylates FOXO3 to promote nuclear exclusion, while activating MDM2 to target p53 for degradation.

Answer

AKT
dephosphorylates IκB to promote nuclear exclusion, while activating RAS to
target p53 for degradation.

Answer

AKT phosphorylates FOXO3 to promote nuclear retention, while activating p53 transcription factor expression directly.

Answer

AKT dephosphorylates STAT3 to promote nuclear export, while activating ETS transcription factor expression directly.

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In response to high circulating IGF-1, active AKT regulates multiple downstream ...

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