The active loading of doxorubicin into liposomes using ammonium sulfate gradient works due to doxorubicin being an weak base

DOXIL is effective in targeting cancer because of accumulation in the MPS (mononuclear phagocyte system)

The size of the liposomes is < 10 nm and prevents clearance by kidney filtration

DOXIL’s liposomes have “stealth” properties as the charged phospholipids impart charge-charged repulsion and hence preventing the adsorption of opsonins