Roger is aged 48 years and has recently visited his GP for

an annual check-up. He has a fasting blood sample collected as well as his

weight, height, and blood pressure assessed. Roger’s BMI is 30 kg/m² and he shows signs of hyperglycaemia (9.6 mmol/L, which

is above the 7.0 mmol/L threshold for diabetes) and dyslipidaemia (HDL

cholesterol of 0.96 mmol/L, meeting the metabolic syndrome criteria of <1.03

mmol/L for men).

Part A.  According to his BMI, what category would Roger be classified as? (1 mark)

Part B. Describe the tissues affected by insulin resistance, which leads to hyperglycaemia and an altered lipid profile (5 marks)

Part C. 

Roger

returns to his GP 12 months later. His blood glucose levels have shown some

improvement (7.8 mmol/L), however, his BMI has increased to 34 kg/m². His GP

prescribes Semaglutide. List 2 mechanisms/pathways by which this pharmacotherapy

will reduce body weight and improve glucose metabolism? (2 marks)