The cytokine IL4 (interleukin 4) promotes immunoglobulin class switch recombination (CSR) at the heavy chain locus to IgG1 and IgE in mouse B cells. Which of the following statements is true in this context.

Question

Answer

IL4 acts to target activation induced cytidine deaminase (AID) to the S regions adjacent to IgG1 and IgE.

Answer

IL4 activates activation induced cytidine deaminase (AID), making double strand breaks in S-region DNA more likely and thus more switching.

Answer

IL4 promotes activation induced cytidine deaminase (AID) activity in general, with the isotype chosen by TLR ligands binding to the B cell.

Answer

IL4 increases B cell proliferation and CSR isotype selection is closely related to cell division number

Crowdly

The cytokine IL4 (interleukin 4) promotes immunoglobulin class switch recombinat...

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