Inducible knockout mouse models permit temporal control over the induction of specific gene knockouts. Tamoxifen is commonly used to induce Cre-mediated recombination in mouse models. How does tamoxifen act?

Question

Inducible knockout mouse models permit temporal control over the induction of specific gene knockouts. Tamoxifen is commonly used to induce Cre-mediated recombination in mouse models. How does tamoxifen act?

Accepted Answer

Promoting nuclear translocation of Cre-ER fusion proteins

Answer

Inducing translation of  Cre  mRNA into protein

Answer

Modifying DNA to facilitate access to  LoxP  sites when Cre is present

Answer

Promoting nuclear translocation of  Cre  mRNA

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Inducible knockout mouse models permit temporal control over the induction of sp...

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