How
do monogenic mutations in the Leptin Receptor (LepR) differ phenotypically from
Congenital Leptin Deficiency?

Question

Accepted Answer

LepR
mutations result in elevated circulating leptin, but the brain cannot respond
to the signal, whereas Congenital Leptin Deficiency involves no circulating
leptin.

Answer

Individuals
with LepR mutations respond dramatically to exogenous leptin therapy.

Answer

LepR mutations result in very low or absent circulating leptin levels.

Answer

LepR mutations cause late-onset obesity that only appears after age 40.

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How do monogenic mutations in the Leptin Receptor (LepR) differ phenotypically f...

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