Which mechanism describes the action of second-generation sulfonylureas (e.g., Glimepiride) in treating Type 2 diabetes, and what is their typical duration of action?

Question

Answer

Activate PPAR-γ for lipid/glucose gene modulation; used in dual PPAR agonists like Saroglitazar.

Answer

Bind ATP-dependent K⁺ channels on β-cells, depolarize to increase Ca²⁺ and insulin secretion; long duration (~24 hours).

Answer

Inhibit DPP-4 to increase incretin levels; short duration (~12 hours).

Answer

Inhibit α-amylase for delayed sugar breakdown; first-line for gestational diabetes.

Answer

Block SGLT-2 in kidneys for 90% glucose reabsorption inhibition; beneficial in heart/kidney disease.

Crowdly

Which mechanism describes the action of second-generation sulfonylureas (e.g., G...

Хочете миттєвий доступ до всіх перевірених відповідей на e-learning.msa.edu.eg?