“Clonal selection” refers to antigen selecting the B cell into the response. For a protein antigen in this initiation process, the B cell antigen receptor:

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pre-existed prior to the appearance of the antigen

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is activated, which triggers the B-cell to undergo proliferation

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changes to fit the antigen

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undergoes class-switch recombination in response to the antigen binding

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“Clonal selection” refers to antigen selecting the B cell into the response. For...

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