Based on the Warburg model in your
lecture slides, what ATP yield per mole of glucose is generated under aerobic
glycolysis, and how do MCT1 and MCT4 function co-dependently within the tumour
microenvironment?

Question

Accepted Answer

~4 mol ATP/mol glucose; MCT4 mediates lactate
efflux from glycolytic cells, whereas MCT1 mediates lactate influx into
oxidative cells for utilisation.

Answer

~30
mol ATP/mol glucose; MCT4 imports glutamine while MCT1 exports pyruvate.

Answer

~36
mol ATP/mol glucose; MCT1 exports lactate from hypoxic cells while MCT4 imports
lactate into oxygenated cells.

Answer

~2
mol ATP/mol glucose; MCT1 and MCT4 both exclusively export lactate to
hyper-acidify the extracellular matrix.

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Based on the Warburg model in your lecture slides, what ATP yield per mole of gl...

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