Dr Amy Farrah Fowler has submitted an animal ethics application proposing
to test the beneficial effects of a new drug that prevents inflammation in a
permanent middle cerebral artery occlusion mouse model of stroke. She is excited to test this treatment in an animal model of stroke with the goal to translate into humans. However, the animal
ethics committee are very concerned that the mice subjected to this severe stroke model will be painful for the animals and they may have
difficulties eating after surgery. Which
of the following is the MOST appropriate change that would satisfy both
researcher and the animal ethics committee?

Question

Dr Amy Farrah Fowler has submitted an animal ethics application proposing
to test the beneficial effects of a new drug that prevents inflammation in a
permanent middle cerebral artery occlusion mouse model of stroke. She is excited to test this treatment in an animal model of stroke with the goal to translate into humans. However, the animal
ethics committee are very concerned that the mice subjected to this severe stroke model will be painful for the animals and they may have
difficulties eating after surgery.   Which
of the following is the MOST appropriate change that would satisfy both
researcher and the animal ethics committee?

Answer

Reduce the number of mice used by 50% and offer
unused organs from the animals to other researchers

Answer

Switch to a neuronal cell culture and reduce the
level of oxygen and nutrients to simulate stroke like conditions

Answer

Change to a photothrombotic model of
stroke.  This stroke model causes much
smaller brain damage, with very little pain and no impact on the animals’ ability
to eat

Answer

Closely monitor the mice and euthanase immediately
at the first sign of pain/discomfort

Crowdly

Dr Amy Farrah Fowler has submitted an animal ethics application proposing to te...

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