Regarding hepatic cholesterol
biosynthesis, which statement correctly describes the bioenergetic requirements
and rate-limiting enzymatic regulation?

Question

Accepted Answer

Synthesis originates from 2 Acetyl-CoA molecules, with HMG-CoA reductase (HMGCR) serving as the rate-limiting step.

Answer

HMG-CoA synthase catalyses the final step of cholesterol ring closure.

Answer

Lanosterol is converted directly into mevalonate by SREBP-2.

Answer

Synthesis
occurs exclusively in the mitochondrial matrix, requiring zero ATP input.

Crowdly