During cerebellar development, granule
cell precursors proliferate extensively within the external granular layer
(EGL) before migrating inward to form the internal granular layer. A paediatric
brain tumour is found to arise from cells that remain highly proliferative
within the EGL.

Which pathological event BEST explains
the origin of this tumour?

Question

During cerebellar development, granule
cell precursors proliferate extensively within the external granular layer
(EGL) before migrating inward to form the internal granular layer. A paediatric
brain tumour is found to arise from cells that remain highly proliferative
within the EGL.

Which pathological event BEST explains
the origin of this tumour?

Accepted Answer

Uncontrolled
expansion of granule cell precursor populations normally located in the
external granular layer

Answer

Increased
differentiation of supportive Bergmann glial cells that guide neuronal
migration

Answer

Overproduction of
Purkinje neurons that regulate cerebellar signalling

Answer

Accelerated migration
of granule cells into the internal granular layer

Crowdly

During cerebellar development, granule cell precursors proliferate extensively ...

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