Trace the correct sequence of
molecular events in Reverse Cholesterol Transport (RCT) from peripheral tissue
clearance to biliary excretion:

Question

Accepted Answer

Efflux via ABCA1/ABCG1 to lipid-poor ApoA-I/nascent HDL → esterification by LCAT to mature HDL → hepatic uptake via SR-BI/LDLR →biliary excretion.

Answer

Direct
uptake of free cholesterol by LDL → transformation
to chylomicrons → renal
filtration.

Answer

Efflux
via LDLR to VLDL → degradation
by PCSK9 → lysosomal
storage in vascular smooth muscle.

Answer

Macrophage synthesis of statins → excretion of mevalonate in sweat.

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