During the drug development process referred in Applied session 11 activity 1, where a drug was being developed that bound to the CFTR protein, both the high throughput screen and the patch clamp assay were used. Why were both assays required during the drug development process, given that both techniques are membrane potential assays?

Question

Answer

Both techniques provide an indirect assessment of Cl- ion movement across the membrane, but it’s useful to have two sources of data to assess each drug

Answer

Both techniques provide an direct assessment of Cl- ion movement across the membrane, but it’s useful to have two sources of data to assess each drug

Answer

The high throughput assay provides an indirect assessment of Cl- ion channel openness, whereas the patch clamp provides a direct measurement of Cl- ion movement

Answer

The patch clamp provides an indirect assessment of Cl- ion channel openness, whereas the high throughput assay provides a direct measurement of Cl- ion movement

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During the drug development process referred in Applied session 11 activity 1, w...

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