Josh suffers from anxiety, which is treated effectively with alprazolam.  Josh develops arthritis and is given  a course of Dexamethasone for treatment. Dexamethasone is a known inducer of p-glycoprotein activity and Alprazolam is a known substrate for p-glycoprotein. 

Considering josh’s treatments for anxiety and arthritis, the most likely result of increased p-glycoprotein activity is?