Bacterium clostridium botulinum is a neurotoxin (BoTox) that disrupts the release of acetylcholine at the neuromuscular junction.
What step during fusion for transmitter release, is the botulinum toxin having a direct affect upon?

Question

Bacterium clostridium botulinum is a neurotoxin (BoTox) that disrupts the release of acetylcholine at the neuromuscular junction. 
 What step during fusion for transmitter release, is the botulinum toxin having a direct affect upon?

Answer

The ability to increase intracellular calcium by 500-1000 fold for neurotransmitter release to occur

Answer

It can/will block the terminal voltage-gated calcium channels

Answer

The binding of acetylcholine vesicles to the SNARE complex

Answer

The ability for acetylcholine vesicles to be docked at the active zone

Answer

The ability of acetylcholine to attach to a receptor on the post-synaptic cleft

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Bacterium clostridium botulinum is a neurotoxin (BoTox) that disrupts the releas...

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