In a
defective LDL receptor (LDLR), a defect at the genetic level can affect the 3D
structure of the LDLR. If key substitutions occur in the 4 th ,5 th
and 6 th amino acids from the N-terminus of the polypeptide that
codes for the B part of the LDLR (as shown in the image):

Question

In a
defective LDL receptor (LDLR), a defect at the genetic level can affect the 3D
structure of the LDLR. If key substitutions occur in the 4 th  ,5 th 
and 6 th  amino acids from the N-terminus of the polypeptide that
codes for the B part of the LDLR (as shown in the image):

Answer

Mutations leading to change in 3D structure of LDLR do not affect the
uptake of LDL particles.

Answer

Change in the amino acid sequence affects the 3D structure of the LDLR
since the side chain of the differing amino acids can lead to variations in
intermolecular forces in the tertiary structure.

Answer

The m-RNA codons for the defective LDLR that are affected due to mutation
are GGC, GAC, AAC.

Answer

Change in the amino acid sequence only affects the primary structure of
the LDLR.

Answer

The m-RNA codons for the defective LDLR that are affected due to mutation
are GGC, CGC, UGC.

Crowdly

In a defective LDL receptor (LDLR), a defect at the genetic level can affect th...

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