When neutrophils leave the blood circulation, they first need to bind to blood vessel endothelial cells in a specific manner and at the right location. In this process, the surface integrin on the leukocyte changes from a low affinity state to a high affinity state. What does this mean?

Question

Answer

The strength of binding of the integrin is increased

Answer

The cells accumulate (swarm) to the vessel wall increasing integrin concentration at the site

Answer

The number of integrin molecules that cluster on the cell surface is increased

Answer

The distance that the integrin extends from the cell surface is increased

Crowdly

When neutrophils leave the blood circulation, they first need to bind to blood v...

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