Tumor-associated neutrophils (TANs) facilitate tumorigenesis in platelets, thereby triggering ITP

Extremely high platelet count

CD6+ T cells are activated during the onset of ITP

Antibody binding to various platelet surface structures, like gpIIb-IIIa integrin, makes them susceptible to opsonization and phagocytosis by splenic macrophages

PD-1 is expressed on the cell surface of platelets and is responsible for ITP