The patient previously took medications Hydroxychloroquine (Plaquenil) daily, but currently he did not

find it helpful, because of it hen tense knee and finger pain. To better control the patient’s symptoms,

the rheumatologist begins a medication that increased plasma homocysteine. That changes in the enzyme

kinetics of the biochemical pathway disrupted by this patient’s most likely new medication is best

described by which of the following statements?