Avian influenza viruses preferentially bind α2,3‑linked
sialic acid receptors, whereas human influenza viruses preferentially bind α2,6‑linked receptors found in the upper respiratory tract. In
the scenario where a mutation arises that enhances α2,6‑receptor
binding, increasing upper airway replication and person‑to‑person
transmission of Avian influenza. There is no reduction in viral fitness is
observed due to this mutation.

Given continued circulation in humans, what outcome is most
likely over time?

Question

Avian influenza viruses preferentially bind α2,3‑linked
sialic acid receptors, whereas human influenza viruses preferentially bind α2,6‑linked receptors found in the upper respiratory tract. In
the scenario where a mutation arises that enhances α2,6‑receptor
binding, increasing upper airway replication and person‑to‑person
transmission of Avian influenza. There is no reduction in viral fitness is
observed due to this mutation.

Given continued circulation in humans, what outcome is most
likely over time?

Accepted Answer

The
mutated strain will increase in prevalence relative to parental strains

Answer

Viral
populations will split into lung‑adapted and airway‑adapted lineages

Answer

The
mutation will be eliminated once population immunity develops

Answer

The
mutation will persist only sporadically due to receptor trade‑offs

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Avian influenza viruses preferentially bind α2,3‑linked sialic acid receptors, ...

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