Genome-wide association studies in patients with systemic lupus
erythematosus identify risk variants in genes involved in interferon
signalling, antigen presentation, and regulation of lymphocyte activation. Many
of these variants alter immune signalling thresholds rather than directly
causing tissue damage.

Which interpretation BEST explains how these findings
contribute to understanding the pathogenesis of systemic lupus erythematosus?

Question

Genome-wide association studies in patients with systemic lupus
erythematosus identify risk variants in genes involved in interferon
signalling, antigen presentation, and regulation of lymphocyte activation. Many
of these variants alter immune signalling thresholds rather than directly
causing tissue damage.

Which interpretation BEST explains how these findings
contribute to understanding the pathogenesis of systemic lupus erythematosus?

Answer

The
disease is caused by antibodies targeting erythrocytes, leading to widespread
destruction of red blood cells

Answer

Depleting
B cells negates the genetic predisposition responsible for initiating
autoimmune responses

Answer

Multiple
genetic polymorphisms affecting innate and adaptive immune regulation increase
susceptibility to dysregulated immune activation

Answer

Autoimmune
pathology results primarily from antibodies directed against hepatocytes
causing progressive liver injury

Crowdly

Genome-wide association studies in patients with systemic lupus erythematosus i...

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