An

exceptionally high density of tight-junction endothelial proteins that

sequesters circulating peptide hormones in the perivascular space.

The

complete absence of long-form leptin receptor expression on both POMC and

NPY/AgRP neuronal subpopulations within the nucleus

Extensive

innervation by myelinated primary afferent nociceptors originating directly

from dorsal root ganglia in the spinal cord.