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During lead optimisation, all lead compounds were evaluated using the forced sw...
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During lead optimisation, all lead compounds were evaluated using the forced swim test in mice.
Table 2: Assessment of in vivo efficacy of lead compounds in rodents
In the forced swim test, decreased immobility is considered to be associated with antidepressant activity
Lead Compound | Forced swim test in mice Time mice are immobile (s) |
Placebo | 154 ± 10 |
EL-10(200µmol/kg) | 73 ± 12 |
| EL-11(200µmol/kg) | 146 ± 8 |
EL-12(200µmol/kg) | 117 ± 9 |
EL-13(200µmol/kg) | 162 ± 6 |
Values given as mean ± SEM
Based upon the data shown in Table 2, which of the compounds is MOST LIKELY to be effective in the treatment of patients with severe depression?
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