Analysis of antibody genes from B cells after repeated
antigen exposure reveals many silent mutations throughout the variable region,
but amino acid–altering mutations are concentrated in specific antigen-contact
regions. Which of the following provides the best explanation for the
distribution of mutations within the antibody?

Question

Answer

Replacement
mutations are distributed evenly across the variable gene segment

Answer

The
mutating enzyme introduces mutations only within structural framework regions

Answer

Selection
favours amino acid changes within complementarity determining regions that
influence antigen binding

Answer

Somatic
mutations are eliminated if they alter the antigen-binding site

Crowdly

Analysis of antibody genes from B cells after repeated antigen exposure reveals...

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