The removal

of the C-18 fatty diacid chain to increase the rate of renal clearance.

Modification

of the peptide to allow it to bypass the brainstem and act exclusively on the

reward pathways of the prefrontal cortex.

Conjugation

with ghrelin-O-acyltransferase (GOAT) to allow for acylation and improved

receptor binding.

Specific

amino acid substitutions and the addition of a spacer/fatty diacid chain to

protect the molecule from metabolic degradation and decrease renal clearance,

thereby increasing its half-life