Which of the following steps in the insulin receptor signalling pathway directly give rise to amplification of the signal?

Question

Which of the following steps in the insulin receptor signalling pathway directly give rise to  amplification  of the signal?

Answer

The ligand-bound, dimeric receptor undergoes a conformational change

Answer

Phosphorylated ERK protein stimulates transcription of insulin-responsive genes

Answer

Phosphorylated MEK protein undergoes dephosphorylation

Answer

The phosphorylated receptor catalyses phosphorylation of insulin receptor substrate-1 (IRS-1)

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