A 62-year-old male with a long-standing history of poorly controlled type 2 diabetes
complains of recurrent skin infections and non-healing ulcers on his feet. Laboratory tests
show elevated HbA1c levels.
Considering the underlying metabolic derangements associated with chronic diabetes, what
is the single best explanation for his increased susceptibility to infections?

Question

A 62-year-old male with a long-standing history of poorly controlled type 2 diabetes  
 complains of recurrent skin infections and non-healing ulcers on his feet. Laboratory tests  
 show elevated HbA1c levels. 
 Considering the underlying metabolic derangements associated with chronic diabetes, what  
 is the single best explanation for his increased susceptibility to infections?

Accepted Answer

Decreased protein synthesis leading to a deficiency in immunoglobulins

Answer

Enhanced glycosylation of proteins affecting cellular signaling and function

Answer

Increased proteolysis resulting in a deficit of amino acids necessary for repair

Answer

Elevated glucagon levels promoting gluconeogenesis and immune dysfunction

Answer

Altered lipid metabolism resulting in impaired cell membrane integrity

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A 62-year-old male with a long-standing history of poorly controlled type 2 dia...

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