Mutations in the gene encoding for the leptin

receptor that results in truncation of the receptor and disrupted leptin

signalling.

Mutations in the AgRP/NPY gene and the enzymes that

go on to produce α-MSH that leads to obesity and altered pigmentation.

Mutations in the melanocortin 4 receptor (MC4R),

which is the most common monogenetic cause of obesity.

Loss of function mutations in the leptin gene that

leads to severe obesity in the first months of life.