In the early 1970s, tricyclic antidepressants were
introduced which inhibited the reuptake of both noradrenaline and
serotonin. Whilst effective, these drugs
had many side effects and researchers sought to create antidepressants that
selectively enhanced serotonin neurotransmission. At that time, techniques such as
computer-aided design or large-scale high-throughput screening were not widely
available.

Which approach most likely led to the discovery of the first
selective serotonin reuptake inhibitors?

Question

In the early 1970s, tricyclic antidepressants were
introduced which inhibited the reuptake of both noradrenaline and
serotonin.  Whilst effective, these drugs
had many side effects and researchers sought to create antidepressants that
selectively enhanced serotonin neurotransmission.  At that time, techniques such as
computer-aided design or large-scale high-throughput screening were not widely
available.

Which approach most likely led to the discovery of the first
selective serotonin reuptake inhibitors?

Answer

Screening thousands
of compounds using automated high-throughput assays

Answer

Systematic structural
modification of existing drugs with weak serotonin reuptake blocking properties
to improve efficacy

Answer

The compound was
likely discovered through serendipity

Answer

Isolating
biologically active serotonin-modulating molecules from microbial sources

Crowdly

In the early 1970s, tricyclic antidepressants were introduced which inhibited t...

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