Female reproductive ageing is associated with a marked
increase in meiotic errors, leading to chromosomal aneuploidy in oocytes.
Proper chromosome segregation during meiosis depends on the maintenance of
cohesion between chromatids over extended periods, a process that can become
compromised with age. Separase and cohesin are required for effective
chromosomal segregation.

Which mechanism best accounts for the increased
incidence of aneuploidy in oocytes from older females?

Question

Female reproductive ageing is associated with a marked
increase in meiotic errors, leading to chromosomal aneuploidy in oocytes.
Proper chromosome segregation during meiosis depends on the maintenance of
cohesion between chromatids over extended periods, a process that can become
compromised with age. Separase and cohesin are required for effective
chromosomal segregation.

Which mechanism best accounts for the increased
incidence of aneuploidy in oocytes from older females?

Accepted Answer

Age-related
loss of cohesin weakens chromosome cohesion, increasing the risk of premature
chromatid separation during meiotic divisions

Answer

Complete
failure of separase activation arrests meiosis in ageing oocytes, preventing
the correct segregation of chromosomes

Answer

Excessive
accumulation of cohesin prevents chromosomes from separating efficiently during
meiotic divisions

Answer

Oxidative
damage and reduced amounts of the separase enzyme disrupts chromosome segregation

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Female reproductive ageing is associated with a marked increase in meiotic erro...

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