In chemical and biological engineering, which situation would be categorised as high likelihood and high consequence?

Question

In chemical and biological engineering, which situation would be categorised as  high likelihood  and  high consequence ?

Answer

A minor leak in a non-toxic chemical storage tank.

Answer

The need for frequent recalibration of lab equipment.

Answer

An uncontrolled reaction leading to an explosion in a chemical plant.

Answer

A chemical reaction proceeding slower than expected, causing minor delays.

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