What scenario would cause the chloride ion channel within CFTR to be unable to open (remain stuck in the closed conformation)?

Question

Answer

A mutation in the transmembrane domain that interrupts ATP binding

Answer

A mutation within the ATP binding cassette domain that keeps the two ATP binding cassette domains close together at all times

Answer

A mutation in the ATP binding cassette domain that interrupts ATP binding

Answer

A mutation within the transmembrane domains that causes the domains to be stuck in a conformation where they are parallel to one another

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