One major difference between the use of peptides or non-peptides as transmitters is that

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Transmission using peptides is faster than when using non-peptide transmitters

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Peptidergic transmission is less dependent on Ca ++

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Peptides are synthesized in the cell body whereas non-peptides are synthesized in the terminal

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Peptidergic transmission involves the use of microtubules while non-peptide transmission depends on active zones

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Peptides are not stored in vesicles as are non-peptide transmitters

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