A 6-year-old girl is brought to the pediatrician by her parents due to concerns about her frequent falls and fractures. Radiographic imaging reveals thin and deformed long bones. Her past medical history includes multiple hospitalizations for fractures
Which most accurately explains the structural defect in the collagen of this patient?

Question

A 6-year-old girl is brought to the pediatrician by her parents due to concerns about her frequent falls and fractures. Radiographic imaging reveals thin and deformed long bones. Her past medical history includes multiple hospitalizations for fractures 
 Which most accurately explains the structural defect in the collagen of this patient?

Answer

Mutation leading to an unfolded triple helix at the N-terminal end of collagen

Answer

Incorrect disulfide bond formation in collagen, leading to skin fragility.

Answer

Decreased synthesis of collagen due to vitamin C deficiency.

Answer

Abnormal hydroxylation of lysine in collagen molecules

Answer

Overproduction of elastin in the connective tissue leading to excessive skin elasticity

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A 6-year-old girl is brought to the pediatrician by her parents due to concer...

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