Random antigen receptor generation during development produces
a lymphocyte population comprising both foreign and self-antigen recognition.
Mechanisms of tolerance act at multiple stages to prevent harmful, anti-self immune
responses.

Which observation would provide the strongest evidence that
immune tolerance has failed in an individual?

Question

Random antigen receptor generation during development produces
a lymphocyte population comprising both foreign and self-antigen recognition.
Mechanisms of tolerance act at multiple stages to prevent harmful, anti-self immune
responses.

Which observation would provide the strongest evidence that
immune tolerance has failed in an individual?

Accepted Answer

Detection
of activated lymphocytes responding to self-antigens in the absence of
infection

Answer

Prolonged
production of antigen-specific B cells after pathogen infection

Answer

Failure
to generate memory lymphocytes following repeated antigen exposure

Answer

Increased
efficiency of germinal centre selection for high-affinity antibodies

Crowdly

Random antigen receptor generation during development produces a lymphocyte pop...

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