What are the potential adverse effects linked to the administration of anti-CTLA-4 monoclonal antibodies in the therapeutic management of cancer?

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Increased levels of amino acid substitutions in tumor cell-derived antigens (neoantigens)

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Reactivation of T regulatory cells in the spleen

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Upregulation of the antigen processing machinery

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Lymphoproliferative disorders based on CD8

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The development of autoimmune diseases

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