During early B cell development, gene segments encoding
antibody variable regions undergo rearrangement to generate diverse antigen
receptors.

Which mechanism contributes most directly to the
enormous number of potential antigen specificities generated before antigen
exposure?

Question

During early B cell development, gene segments encoding
antibody variable regions undergo rearrangement to generate diverse antigen
receptors.

Which mechanism contributes most directly to the
enormous number of potential antigen specificities generated before antigen
exposure?

Answer

Cooperation
between B cell and T cell antigen receptors

Answer

Somatic
hypermutation occurring after antigen stimulation

Answer

Random
recombination of multiple variable gene segments during receptor assembly

Answer

Selection
of high-affinity B cells during germinal centre reactions

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