How can autoreactive B cells contribute to the pathogenesis of autoimmune diseases?

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Autoreactive B cells form ectopic lymphoid structures in tissues by forming immune complexes with other immune cells

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Autoreactive B cells present antigens to antigen presenting cells to stimulate T cells

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Autoantibodies derived from autoreactive B cells recognise self-antigens and form immune-complex deposition in organs triggering inflammation

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Autoreactive B cells produce granzyme to destroy own tissues

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