What experiment showed that the HOXD13 gene may have had a central role in the fin to limb transition over evolution?

Question

What experiment showed that the  HOXD13  gene may have had a central role in the fin to limb transition over evolution?

Accepted Answer

Mis-expression of  Hoxd13  in the fish fin fold causes limb-like structures to form

Answer

Expression analysis shows  Hoxd13  mRNA is present in limb buds of both fishes and mouse

Answer

Mouse embryos over-expressing  Hoxd13  develop fins, with long bony fin rays

Answer

Knock out of  Hoxd13  in the zebrafish fin bud induces mouse forelimb formation

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