Biopsies from affected tissues in autoimmune disease reveal
dense infiltrates of activated CD4⁺ helper T cells and CD8⁺ cytotoxic T cells
producing inflammatory cytokines such as IFN‑γ
and TNF. No infectious organisms are detected, and host cells display
self-antigens.

Which explanation BEST accounts for how these T
cells contribute to disease progression?

Question

Biopsies from affected tissues in autoimmune disease reveal
dense infiltrates of activated CD4⁺ helper T cells and CD8⁺ cytotoxic T cells
producing inflammatory cytokines such as IFN‑γ
and TNF. No infectious organisms are detected, and host cells display
self-antigens.

Which explanation BEST accounts for how these T
cells contribute to disease progression?

Answer

Autoreactive
T cells recognise self-antigens and drive inflammation and cytotoxic tissue
injury

Answer

Regulatory
T cells activate effector cells to clear pathogens but contribute to an
increase in inflammation

Answer

T
cells suppress inflammation by inhibiting cytokine production within the
impacted tissues

Answer

T
cells differentiate into antibody-secreting cells which create autoantibodies
against host antigens

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Biopsies from affected tissues in autoimmune disease reveal dense infiltrates o...

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