A patient in intensive care has a bloodstream infection
caused by a carbapenem-resistant Acinetobacter baumannii s train. Initial treatment uses colistin, a polymyxin
antibiotic. During treatment, colistin resistance evolves. What is the most
likely mechanism of colistin resistance?

Question

A patient in intensive care has a bloodstream infection
caused by a carbapenem-resistant  Acinetobacter baumannii s train.  Initial treatment uses colistin, a polymyxin
antibiotic. During treatment, colistin resistance evolves. What is the most
likely mechanism of colistin resistance?

Accepted Answer

Mutation
in  lpxC , resulting in compete loss of LPS biosynthesis

Answer

Mutation
resulting in a missense amino acid substitution in the target RNA polymerase

Answer

Acquisition
of a new beta-lactamase gene on a plasmid

Answer

Mutation
in the 16S ribosomal RNA gene, leading to an altered ribosomal structure

Crowdly

A patient in intensive care has a bloodstream infection caused by a carbapenem-...

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