During a skin examination, a
dermatologist explains that dysplastic nevi are monitored carefully because
they can sometimes represent early stages of melanoma development.

Why are individuals with many dysplastic nevi
considered at higher risk of melanoma?

Question

During a skin examination, a
dermatologist explains that dysplastic nevi are monitored carefully because
they can sometimes represent early stages of melanoma development.

Why are individuals with many dysplastic nevi
considered at higher risk of melanoma?

Answer

Dysplastic nevi cause
neighbouring keratinocytes to secrete growth factors that permanently stimulate
melanocyte division

Answer

Some
dysplastic nevi contain melanocytes with early oncogenic mutations that can
accumulate additional changes and progress to melanoma

Answer

Dysplastic nevi
prevent DNA repair pathways from functioning in surrounding skin cells

Answer

Dysplastic nevi
increase UV absorption in the skin, which directly converts normal melanocytes
into melanoma cells

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During a skin examination, a dermatologist explains that dysplastic nevi are mo...

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