A 34-year-old male presents with a 3-month history of symmetric joint pain and stiffness. Labs show positive anti-CCP, positive RF, and an ESR of 32 mm/hr. His Patient Activity Scale (PAS) score is 2.5. What is the most appropriate initial treatment?

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Answer

Methotrexate 7.5 mg PO once weekly + folic acid + a short course of prednisone.

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Sulfasalazine monotherapy.

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Adalimumab 40 mg subcut every other week.

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Hydroxychloroquine monotherapy.

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Methotrexate 7.5 mg PO once weekly + folic acid.

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A 34-year-old male presents with a 3-month history of symmetric joint pain and s...

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