A mutation is introduced into a
signalling protein that prevents RAS from binding GTP while leaving its
GDP-bound form intact. Cells expressing this mutant protein show dramatically
reduced proliferation.

Which step in the activation of B-RAF
is most directly disrupted?

Question

A mutation is introduced into a
signalling protein that prevents RAS from binding GTP while leaving its
GDP-bound form intact. Cells expressing this mutant protein show dramatically
reduced proliferation.

Which step in the activation of B-RAF
is most directly disrupted?

Accepted Answer

The
recruitment of B-RAF to active RAS-GTP at the membrane and the formation of RAF
dimers required for kinase activation

Answer

The assembly of B-RAF
with SOS at the membrane to activate downstream MAPK signalling

Answer

The binding of B-RAF
to inactive RAS-GDP followed by phosphorylation by SOS

Answer

The activation of
B-RAF through direct phosphorylation by RAS after receptor stimulation

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A mutation is introduced into a signalling protein that prevents RAS from bindi...

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