The structure of a drug, not the molecular weight governs if the drug will be able to bind to the cyclodextrin binding pocket

The hydrophilic core of cyclodextrin is the driving force for drug loading

Cholesterol can displace drugs from the core of cyclodextrin

If a drug is solubilised by alpha-cyclodextrin, then gamma cyclodextrin will be as good or better at solubilising the drug