In female obesity, how does elevated circulating leptin paradoxically disrupt ovarian steroidogenesis and hypothalamic-pituitary-gonadal signalling?

Question

Accepted Answer

Leptin directly inhibits insulin-induced steroidogenesis in granulosa cells, while central leptin resistance impairs GnRH/LH drive.

Answer

Leptin directly suppresses adrenal androgen synthesis, while central leptin hypersensitivity induces excessive pituitary LH release.

Answer

Leptin directly degrades circulating LH and FSH gonadotropins, while central leptin resistance triggers precocious ovulation.

Answer

Leptin directly stimulates ovarian aromatase while blocking pituitary FSH release, resulting in systemic progesterone deficiency.

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