T cell–dependent antibody responses require precise spatial
and temporal coordination between antigen-specific B cells and CD4⁺ helper T
cells. After antigen encounter, both cell types undergo regulated changes in
chemokine receptor expression that guide their migration within secondary
lymphoid organs.

Which finding best demonstrates that this
coordinated cellular migration is occurring normally?

Question

T cell–dependent antibody responses require precise spatial
and temporal coordination between antigen-specific B cells and CD4⁺ helper T
cells. After antigen encounter, both cell types undergo regulated changes in
chemokine receptor expression that guide their migration within secondary
lymphoid organs.

Which finding best demonstrates that this
coordinated cellular migration is occurring normally?

Answer

B
cells and T cells remain within germinal centres

Answer

Dendritic
cells simultaneously maintain long-term contact with both lymphocyte types

Answer

Activated
T cells immediately disperse uniformly throughout the germinal centre allowing
interaction with B cells

Answer

Antigen-reactive
B cells and CD4⁺ T cells localise at the follicle–T zone interface

Crowdly

T cell–dependent antibody responses require precise spatial and temporal coordi...

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