Drug absorption in the rectum occurs primarily through transcellular diffusion. Which physicochemical property of a drug best facilitates transport by this mechanism?

Question

Answer

Very small drug particles, below50 μm, to increase agglomeration.

Answer

Always in ionized form due to the neutral pH of the rectum.

Answer

Very hydrophilic and has a high molecular weight.

Answer

Has a low partition coefficient between the vehicle and rectal fluid.

Answer

Non-ionized drugs more easily pass through cell membranes transcellularly.

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Drug absorption in the rectum occurs primarily through transcellular diffusion. ...

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