A new monoclonal antibody directed to
a tumour antigen is tested against a panel of tumour cells in the presence or
absence of innate immune cells. Tumour cell death occurs only when innate
immune cells expressing Fc gamma receptor III (CD16) are present. In contrast,
chemical inhibition of the complement cascade has no effect on tumour killing.

Which mechanism most likely explains
how this antibody mediates tumour cell death?

Question

A new monoclonal antibody directed to
a tumour antigen is tested against a panel of tumour cells in the presence or
absence of innate immune cells. Tumour cell death occurs only when innate
immune cells expressing Fc gamma receptor III (CD16) are present. In contrast,
chemical inhibition of the complement cascade has no effect on tumour killing.

Which mechanism most likely explains
how this antibody mediates tumour cell death?

Answer

Antibody triggers
complement activation, leading to lysis of tumour cells

Answer

Antibody-bound
tumour cells engage Fc gamma receptors on innate immune cells, inducing
targeted cytotoxicity

Answer

Antibody activates
death receptors on tumour cells independently of immune cells

Answer

Antibody blocks
tumour cell growth factor signalling, indirectly causing apoptosis

Crowdly

A new monoclonal antibody directed to a tumour antigen is tested against a pane...

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